Fluta-cell 250 Mechanism of Action

Pharmacology: Flutamide (Fluta-cell) is a non-steroidal antiandrogen. It is a type of hormone therapy. Flutamide has shown potent anti-androgenic effects. The basis for its anti-androgenic action is inhibition of androgen uptake and/or inhibition of nuclear binding in the target organs. If Flutamide is administered in combination with surgical or medical castration, both testicular and adrenal androgen activity is surpassed.
Pharmacokinetics: Flutamide (Fluta-cell) is well absorbed after oral ingestion.
Appropriate tests performed with radiolabelled Flutamide showed that the active ingredient is rapidly and extensively converted into its metabolites which are detectible in plasma for up to 8 hours after administration. Within the first two days, approximately 46% of the administered dose is excreted via the urine and 2% via the faeces. The radiolabel is removed by metabolism, so that excretion appears to slow down due to retention of the label as titrated water. Accordingly, excretion and metabolism are practically complete within two days.